I think we are all just learning how overwhelming and suffocating 'stuff' can be check out this video:
I've actually been feeling this urge to "organize" my stuff lately and I think the reality is I just have more than I can deal with. I have found that my large home has accumulated with "stuff" and it does stress me out. We have actually contemplated moving at times but love our neighborhood....so we'll stay but I do a have get rid of stuff to-do list!
This is easier said then done when we work and have the kids but I've done it before, just one room at a time. I usually put down some toys and baskets and let the kids play and sort. I'm just super strict and if it isn't getting used it goes. If there is too much to deal with or we have to move on I just get back to it later. We all have small closets and don't buy a lot of cloths so mainly it is toys and housewares or gifts and gadgets (half started projects I thought would be cool or things we have just outgrown as a family). I don't deal with garage sales I just donate and giveaway.
The trick is not accumulating so much new stuff that I have to start all over again once I'm done. If there was ever a time we needed to simplify it looks like today's environment has really been trying to tell us something. Are you hearing the call to de-stuff too?